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Main Category: Infectious Diseases / Bacteria / Viruses
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Progenics Pharmaceuticals, Inc. (Nasdaq: PGNX) proclaimed the introduction of presymptomatic information on new monoclonal antibodies against toxins produced by the bacteria Clostridium difficile (C. difficile). The monoclonal antibodies efficaciously neutralised the cell-killing activities of the toxins in vitro and importantly improved selection in a rigorous sensual modeling of C. difficile transmission. C. difficile is the lead crusade of hospital-acquired looseness in the United States and represents a growth world world wellness dispute. The monoclonal antibodies were identified as role of the Company’s on-going dose breakthrough efforts in infective diseases. The information were presented at the cx General Meeting of the American Society for Microbiology in San Diego.
C. difficile-associated disease typically occurs when an soul is open to this pathogen piece fetching antibiotics , since a class of antibiotic intervention can interrupt the rule enteric bacterium and cater an chance for transmission in the colon. The C. difficile bacterium get two toxins, A and B, that can hurt cells that job the colon, and can solvent in mild-to-severe diarrhoea and, in approximately cases, potentially serious inflaming of the colon.
“The find of refreshing monoclonal antibodies to C. difficile toxins leverages our expertness in antibody exploitation, infective diseases and gastroenterology,” declared Paul J. Maddon, M.D., Ph.D., Founder, Chief Executive Officer and Chief Science Officer of Progenics. “Our antibodies symbolize a non-antibiotic discourse scheme that is intentional to blockage the harmful effects of the toxins patch allowing the colon to mend course and go repopulated with rule bacterium. We aspect advancing to complemental extra presymptomatic studies in edict to prize the optimum antibodies for growing.”
A gore of refreshing murine antitoxin A and antitoxin B monoclonal antibodies was generated by Progenics scientists. The monoclonal antibodies demonstrated toxin-neutralizing activeness at ng per mL concentrations in in vitro studies. A compounding of an antitoxin A antibody and an antitoxin B antibody was time-tested in an brute example of C difficile-associated disease (CDAD). In the survey, animals (n=8/group) were septic with C. difficile in the mien or absence of antibody therapy. Murine antibodies were put-upon in the fauna sketch. Following picture to C. difficile, untreated animals survived for tercet years or less. In demarcation, all animals hardened with Progenics’ antibodies survived to the end of the 37-day bailiwick (P
Humanized forms of the murine antitoxin antibodies were generated and time-tested in vitro for toxin-neutralizing activeness against a impanel of ceremonious and hypervirulent strains of C. difficile. Progenics’ humanized antibodies were well-tried aboard the rear murine antitoxin antibodies and aboard alive comparator antitoxin antibodies, CDA1 and CDB1. Humanized and murine forms of Progenics’ antibodies demonstrated standardized toxin-neutralizing action in vitro.
The notice, entitled, “Novel Monoclonal Antibodies for Treatment of Clostridium difficile-Associated Disease,” is scheduled for introduction on Thursday, May xxvii by Dangshe Ma, Ph.D., Associate Director, Biologics Discovery at Progenics.
About Clostridium difficile and C. difficile-associated disease
Clostridium difficile is a spore-forming bacteria that can infest the intestines and case spartan diarrhoea, colitis (excitement of the great gut), toxic megacolon (life-threatening firing and distension of the big gut), sepsis (grievous contagion in the bloodstream), intestine perforation and, in the almost life-threatening cases, destruction. The bacteria produces spores that can last away the eubstance for months and are immune to ordinarily put-upon cleanup agents. The elementary peril constituent for C. difficile-associated disease (CDAD) is the use of broad-spectrum antibiotics, as they can interrupt rule gi botany, promoting C. difficile gigantism. C. difficile typically affects elderly or gravely ill patients who are infirmary inpatients or residents of long-term-care facilities. Current treatments for CDAD admit flagyl and vancocin; notwithstanding, thither is increasing peril for discussion loser and disease return. The incidence and harshness of CDAD are increasing due in portion to the issue of hypervirulent strains (designated BI/NAP1/027), which develop roughly 20-fold higher amounts of toxins A and B.
Progenics Pharmaceuticals, Inc.
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